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apalutamide will minimize the extent or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medication that happen to be CYP2C19 substrates may end up in lessen exposure to these medications.diazepam improves amounts of lomitapide by